This category includes various medical disorders involving deficiency of one or more components of the immune system.   The listed disorders are systemic lupus erythematosus, systemic vasculitis, systemic sclerosis and scleroderma, polymyositis or dermatomyositis, undifferentiated connective tissue disorders, inflammatory arthritis, allergic disorders and HIV.

Individuls who have been diagnosed with one of the listed disorders are not automatically eligible for disability benefits. To be awarded benefits, they must either present clinical evidence that their disorders have progressed to a very severe level; or they must be able to prove that the symptoms they experience impose functional restrictions that effectively preclude them from working.  

The symptoms of immune system disorders are highly variable.   Pain and fatigue are quite common, as are anxiety and depression. These can have a significant impact on an individual's stamina, as well as on his or her ability to perform the mental functions of competitive work. Many people whose immune system disorders have not yet progressed to a severe level are nonetheless able to qualify for disability benefits based on the limitations imposed by their symptoms.  

Additionally, the treatment of immune system disorders frequently involves administration of high dosages of medications that can produce significant side effects. Careful documentation of these side effects can sometimes make the difference between winning and losing in cases involving immune system disorders.